Description

(S)-3-(4-Fluoro-Benzenesulfonyl)-Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its core value lies in its role as a key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and metabolic disorders. This compound is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in asymmetric synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of complex drug candidates, especially those containing sulfonamide and pyrrolidine pharmacophores.
• Asymmetric Synthesis: Used as a stereochemically defined building block for constructing molecules with high enantiomeric purity in research and development.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• API Development: Integral to the process development and scale-up of potential new chemical entities (NCEs) requiring the (S)-3-(4-fluorobenzenesulfonyl)pyrrolidine moiety.
• Biochemical Tool Compound: Can be utilized in the development of enzyme inhibitors or receptor modulators for biochemical assays.

Basic Information

Product Name	(S)-3-(4-Fluoro-Benzenesulfonyl)-Pyrrolidine Hydrochloride
CAS No.	1354010-06-2
Molecular Formula	C10H12FNO2S • HCl
Molecular Weight	265.73 (Free base) / 302.19 (HCl salt)
Synonyms	(S)-3-[(4-Fluorophenyl)sulfonyl]pyrrolidine hydrochloride; (S)-3-(4-Fluorophenylsulfonyl)pyrrolidine HCl; (S)-N-(4-Fluorobenzenesulfonyl)pyrrolidine-3-amine hydrochloride; Pyrrolidine, 3-[(4-fluorophenyl)sulfonyl]-, hydrochloride, (3S)-; 1354010-06-2; (S)-3-(4-FBS)-pyrrolidine HCl
EINECS	Contact for details

Quality Control

Our (S)-3-(4-Fluoro-Benzenesulfonyl)-Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and chiral excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.