Description

2,3-Dihydro-Benzo[1,4]Dioxine-6-Carboxylic Acid Piperidin-3-Ylamide Hydrochloride is a high-purity, non-racemic chiral building block and advanced pharmaceutical intermediate. This compound is valued for its role in the synthesis of complex molecules, particularly in medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring precise, high-quality intermediates for active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Employed in the synthesis of more complex heterocyclic compounds and proprietary chemical libraries for high-throughput screening.
• Active Pharmaceutical Ingredient (API) Development: Serves as a critical intermediate in the pilot-scale and commercial-scale synthesis of candidate drug molecules.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studies in organic synthesis methodology and bioorganic chemistry.

Basic Information

Product Name	2,3-Dihydro-Benzo[1,4]Dioxine-6-Carboxylic Acid Piperidin-3-Ylamide Hydrochloride
CAS No.	1353948-20-5
Molecular Formula	C15H20N2O3 • HCl
Molecular Weight	312.79 g/mol (Free base: 276.33 g/mol)
Synonyms	1,4-Benzodioxan-6-carboxylic acid, 2,3-dihydro-, 3-(1-piperidinyl)propylamide, monohydrochloride; 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid (3-piperidinopropyl)amide hydrochloride; 6-[(3-Piperidin-1-ylpropyl)carbamoyl]-2,3-dihydro-1,4-benzodioxine hydrochloride; (3-Piperidin-1-ylpropyl)carbamic acid 2,3-dihydro-1,4-benzodioxin-6-yl ester hydrochloride (tautomeric form); Piperidin-3-ylamide derivative of 1,4-benzodioxane-6-carboxylic acid HCl.
EINECS	Contact for details

Quality Control

Our 2,3-Dihydro-Benzo[1,4]Dioxine-6-Carboxylic Acid Piperidin-3-Ylamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) documenting identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.