Description

tert-Butyl ((3S,4S)-4-Aminotetrahydro-2H-Pyran-3-Yl)Carbamate is a high-purity, stereochemically defined chiral building block of significant importance in modern pharmaceutical synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and novel therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications in medicinal chemistry and advanced process chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetics & Protease Inhibitor Synthesis: Used in the construction of peptidomimetic scaffolds and as a precursor for inhibitors targeting specific enzymes.
• API Process Development: Serves as a building block in the research, development, and scale-up of new Active Pharmaceutical Ingredient (API) manufacturing routes.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (3S,4S)-aminotetrahydropyran moiety into target molecules.
• Chemical Biology & Medicinal Chemistry: Utilized in library synthesis for structure-activity relationship (SAR) studies and hit-to-lead optimization campaigns.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis organizations (CSOs) and CDMOs serving the global pharmaceutical market.

Basic Information

Product Name	tert-Butyl ((3S,4S)-4-Aminotetrahydro-2H-Pyran-3-Yl)Carbamate
CAS No.	1350734-62-1
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	Boc-(3S,4S)-4-Amino-3-hydroxypiperidine; (3S,4S)-3-((tert-Butoxycarbonyl)amino)tetrahydro-2H-pyran-4-amine; tert-Butyl N-[(3S,4S)-4-aminotetrahydropyran-3-yl]carbamate; (3S,4S)-4-Amino-N-Boc-3-aminotetrahydropyran; Boc-Amino-THP-amine (stereospecific); 1,1-Dimethylethyl N-[(3S,4S)-4-amino-3,4,5,6-tetrahydro-2H-pyran-3-yl]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl ((3S,4S)-4-Aminotetrahydro-2H-Pyran-3-Yl)Carbamate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC, to ensure high stereochemical purity and chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each batch to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.