Description

{(1R,2R,4R)-4-[(tert-Butoxycarbonyl)-Amino]-2-Hydroxy-Cyclohexyl} Benzene-Carbothioate is a high-purity, chiral organic intermediate of significant importance in advanced pharmaceutical synthesis. Its defined stereochemistry and protected functional groups make it a critical building block for constructing complex, biologically active molecules. This compound is primarily required by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for candidates targeting neurological and metabolic disorders.
• Peptidomimetic Synthesis: Used in the construction of peptide analogs and mimetics where the cyclohexyl scaffold provides conformational rigidity and influences bioavailability.
• Protecting Group Chemistry: The tert-butoxycarbonyl (Boc) protected amine is a standard feature in multi-step organic synthesis, allowing for selective deprotection and further functionalization.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized ligands used in asymmetric catalysis, enhancing the enantioselectivity of chemical transformations.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of specific stereocenters and functional groups on biological activity.
• Custom Synthesis: Provides a foundational structure for contract research and manufacturing organizations (CROs/CMOs) to produce bespoke compounds for client projects.

Basic Information

Product Name	{(1R,2R,4R)-4-[(tert-Butoxycarbonyl)-Amino]-2-Hydroxy-Cyclohexyl} Benzene-Carbothioate
CAS No.	1350636-89-3
Molecular Formula	C18H25NO4S
Molecular Weight	351.46 g/mol
Synonyms	(1R,2R,4R)-4-[(tert-Butoxycarbonyl)amino]-2-hydroxycyclohexyl benzenecarbothioate; (1R,2R,4R)-4-(Boc-amino)-2-hydroxycyclohexyl thiobenzoate; 4-[(tert-Butoxycarbonyl)amino]-2-hydroxycyclohexyl thiobenzoate (stereoisomer); Boc-protected aminohydroxycyclohexyl thiobenzoate; Thiobenzoic acid (1R,2R,4R)-4-[(tert-butoxycarbonyl)amino]-2-hydroxycyclohexyl ester; CAS 1350636-89-3
EINECS	Contact for details

Quality Control

Our production of {(1R,2R,4R)-4-[(tert-Butoxycarbonyl)-Amino]-2-Hydroxy-Cyclohexyl} Benzene-Carbothioate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure consistency and meet the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere when not in use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.