Description

12-(T-Boc-Amino)-1-Dodecyl Methanethiosulfonate is a specialized bifunctional chemical reagent featuring a protected amine group and a reactive methanethiosulfonate moiety. This compound is essential for site-specific protein and peptide modification, enabling controlled bioconjugation and labeling strategies in advanced research. It is primarily utilized by scientists and manufacturers in the fields of bioconjugation chemistry, proteomics, and pharmaceutical development for creating stable, well-defined molecular constructs.

Application

• Site-Specific Protein Labeling: Selective modification of cysteine residues for attaching fluorophores, biotin, or other probes.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serving as a key intermediate in the synthesis of cleavable or non-cleavable linkers for targeted therapeutics.
• Surface Immobilization: Functionalization of gold surfaces or nanoparticles via the thiol-reactive group for biosensor and diagnostic assay development.
• Peptide Synthesis & Modification: Introduction of protected amine handles or cross-linking groups into synthetic peptide chains.
• Polymer Conjugation: Crafting functionalized polymers for drug delivery systems by reacting with thiol-containing biomolecules.
• Biophysical Studies: Creating spin-labeled or chemically tagged proteins for structural analysis via techniques like EPR spectroscopy.

Basic Information

Product Name	12-(T-Boc-Amino)-1-Dodecyl Methanethiosulfonate
CAS No.	1346598-35-3
Molecular Formula	C18H37NO4S2
Molecular Weight	395.62 g/mol
Synonyms	1-Dodecyl methanethiosulfonate, 12-[(tert-Butoxycarbonyl)amino]dodecyl; 12-(Boc-Amino)dodecyl Methanethiosulfonate; Boc-NH-(CH2)12-SSO2CH3; tert-Butyl (12-(methanesulfonothioyloxy)dodecyl)carbamate; MTSL-Boc-NH-C12; Boc-C12-MTS; Long-chain Boc-protected amino MTS reagent
EINECS	Contact for details

Quality Control

Our production of 12-(T-Boc-Amino)-1-Dodecyl Methanethiosulfonate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, critical for sensitive bioconjugation applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We maintain ISO 9001 quality management standards, and our processes are designed to meet the exacting requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The product is light-sensitive and should be handled under controlled conditions to prevent decomposition. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.