Description

4-(2,4-Difluorophenyl)Tetrahydro-2H-Pyran-4-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorophenyl-substituted tetrahydropyran scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific fluorine substitution for enhanced metabolic stability and bioavailability. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drugs, especially in central nervous system (CNS) and anti-infective therapeutic categories.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides, where the difluorophenyl group can influence biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Potential building block for specialty polymers or advanced organic materials with specific electronic properties.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	4-(2,4-Difluorophenyl)Tetrahydro-2H-Pyran-4-Amine
CAS No.	1343080-01-2
Molecular Formula	C11H13F2NO
Molecular Weight	213.22 g/mol
Synonyms	4-Amino-4-(2,4-difluorophenyl)tetrahydro-2H-pyran; 4-(2,4-Difluorophenyl)-4-aminotetrahydropyran; 4-(2,4-Difluorophenyl)tetrahydropyran-4-amine; 2H-Pyran-4-amine, tetrahydro-4-(2,4-difluorophenyl)-; 4-(2,4-Difluorophenyl)-4-aminotetrahydro-2H-pyran; 1343080-01-2; 4-(2,4-Difluorophenyl)tetrahydro-2H-pyran-4-amine
EINECS	Contact for details

Quality Control

Our 4-(2,4-Difluorophenyl)Tetrahydro-2H-Pyran-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.