Description

But-3-Yne-1-Sulfonamide is a specialized organic building block featuring a terminal alkyne group linked to a sulfonamide moiety, offering versatile reactivity for advanced synthesis. This compound is valued for its role as a key intermediate in the development of pharmaceuticals, agrochemicals, and functional materials. It is primarily sought by research institutions and industrial manufacturers engaged in medicinal chemistry, chemical biology, and material science for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators that require sulfonamide-based structures.
• Click Chemistry Reagent: The terminal alkyne group makes it an ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, facilitating bioconjugation and polymer functionalization.
• Material Science: Serves as a monomer or cross-linking agent in the creation of specialty polymers, coatings, and resins with tailored properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and protein interactions.
• Organic Synthesis: A versatile synthon for constructing complex heterocycles and sulfonamide-containing compounds via Sonogashira coupling and other cross-coupling reactions.

Basic Information

Product Name	But-3-Yne-1-Sulfonamide
CAS No.	1341659-00-4
Molecular Formula	C₄H₇NO₂S
Molecular Weight	133.17 g/mol
Synonyms	3-Butyn-1-sulfonamide; But-3-yn-1-sulfonamide; 3-Butyne-1-sulfonamide; 1-Sulfamoylbut-3-yne; 3-Butynylsulfonamide; But-3-ynylsulfonamide; 4-Sulfamoyl-1-butyne
EINECS	Contact for details

Quality Control

Our But-3-Yne-1-Sulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.