Description

(Tetrahydro-Pyran-3-Yl)-Methanesulfonyl Chloride is a high-purity sulfonyl chloride derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a versatile reagent for introducing the methanesulfonyl (mesyl) group, enabling precise molecular modifications and the construction of complex chemical architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to create novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs and targeted covalent inhibitors.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the sulfonyl moiety enhances biological activity.
• Peptide & Protein Modification: Employed as a selective modifying agent for amino acid side chains in bioconjugation and probe development.
• Polymer & Material Science: Serves as a functional monomer or cross-linking agent for creating specialty polymers with tailored properties.
• Chemical Biology Probe Development: Utilized to synthesize activity-based probes for studying enzyme function and mechanism.
• Scale-Up Process Chemistry: An important building block for the kilogram-scale production of drug candidates during clinical development.

Basic Information

Product Name	(Tetrahydro-Pyran-3-Yl)-Methanesulfonyl Chloride
CAS No.	1341053-94-8
Molecular Formula	C7H13ClO3S
Molecular Weight	212.69 g/mol
Synonyms	3-(Chlorosulfonylmethyl)tetrahydropyran; Tetrahydropyran-3-ylmethanesulfonyl chloride; (Oxan-3-yl)methanesulfonyl chloride; (THP-3-yl)methanesulfonyl chloride; 3-(Methanesulfonyl chloride)tetrahydropyran; (3-Tetrahydropyranyl)methanesulfonyl chloride; Mesyl chloride, (tetrahydro-3-pyranyl)-; (Tetrahydro-3-pyranyl)methyl sulfonyl chloride
EINECS	Contact for details

Quality Control

Our (Tetrahydro-Pyran-3-Yl)-Methanesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.