Description

tert-Butyl ((3R,4R)-3-Aminotetrahydro-2H-Pyran-4-Yl)Carbamate is a high-purity, stereochemically defined chiral building block of significant value in advanced organic synthesis. This compound matters as a key protected intermediate for constructing complex molecules with precise three-dimensional architecture, which is critical for developing pharmaceuticals with targeted biological activity. It is primarily needed by research and development chemists and process development teams in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in areas requiring sophisticated chiral scaffolds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and commercial-scale synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Peptidomimetic Chemistry: Serves as a constrained, non-natural amino acid analog for constructing peptide-like molecules with enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Process Chemistry Development: Employed in developing robust, scalable synthetic routes for GMP production of active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective reactions to introduce the (3R,4R) configuration into target molecules.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	tert-Butyl ((3R,4R)-3-Aminotetrahydro-2H-Pyran-4-Yl)Carbamate
CAS No.	1340474-87-4
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	(3R,4R)-4-[(tert-Butoxycarbonyl)amino]tetrahydro-2H-pyran-3-amine; Boc-(3R,4R)-3-Amino-4-aminotetrahydro-2H-pyran; (3R,4R)-3-Amino-N-Boc-tetrahydropyran-4-amine; tert-Butyl N-[(3R,4R)-3-aminotetrahydropyran-4-yl]carbamate; (3R,4R)-3-Amino-4-(Boc-amino)tetrahydropyran; Boc-Amino-(3R,4R)-tetrahydropyranylamine; (3R,4R)-4-(Boc-amino)-3-aminotetrahydropyran
EINECS	Contact for details

Quality Control

Our tert-Butyl ((3R,4R)-3-Aminotetrahydro-2H-Pyran-4-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity and identity, to ensure compliance with stringent industry standards for advanced pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.