Description

2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-4-Yl)Ethan-1-One is a high-purity fluorinated ketone building block, essential for introducing the trifluoroacetyl and tetrahydropyranyl motifs into complex molecular architectures. Its value lies in enabling precise chemical modifications that enhance the metabolic stability, lipophilicity, and binding affinity of target compounds. This intermediate is critically needed by pharmaceutical and agrochemical R&D teams for the synthesis of advanced active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry for creating fluorinated analogs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorine atom improves biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and advanced organic electronic materials requiring specific fluorine content.
• Chemical Biology & Proteomics: Employed as a reactive handle or labeling agent in the study of protein interactions and biochemical pathways.
• Organic Synthesis: A versatile reagent for Friedel-Crafts acylation, Grignard reactions, and as a precursor for heterocyclic compounds.
• Fluorine Chemistry Development: Used in methodological research to explore new C-F bond formation and functional group transformations.

Basic Information

Product Name	2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-4-Yl)Ethan-1-One
CAS No.	1339671-20-3
Molecular Formula	C7H9F3O2
Molecular Weight	182.14 g/mol
Synonyms	4-(2,2,2-Trifluoroacetyl)tetrahydro-2H-pyran; 1-(Oxan-4-yl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(tetrahydro-2H-pyran-4-yl)ethanone; 4-(Trifluoroacetyl)tetrahydro-2H-pyran; TFAP; Trifluoroacetyl tetrahydropyran; α,α,α-Trifluoro-4-pyranyl methyl ketone
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(Tetrahydro-2H-Pyran-4-Yl)Ethan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.