Description

tert-Butyl 4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridazin-1(2H)-Yl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core and a protected boronic ester functional group. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through key cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) for clinical trials and commercial production.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester moiety makes it an essential reagent for constructing biaryl and heterobiaryl structures, a fundamental transformation in drug discovery.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop novel small-molecule therapeutics.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the construction of linker components for bifunctional molecules designed for targeted protein degradation.
• Chemical Biology Probes: Utilized to create labeled or tagged molecules for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Supports the transition from milligram-scale discovery to kilogram-scale manufacturing under GMP conditions.

Basic Information

Product Name	tert-Butyl 4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridazin-1(2H)-Yl)Piperidine-1-Carboxylate
CAS No.	1333222-17-5
Molecular Formula	C20H34BN3O4
Molecular Weight	391.32 g/mol
Synonyms	1-Boc-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridazin-1(2H)-yl)piperidine; tert-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridazin-1-yl]piperidine-1-carboxylate; 1,1-Dimethylethyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridazin-1-yl]-1-piperidinecarboxylate; 1-Boc-4-(5-(pinacolboryl)pyridazin-1(2H)-yl)piperidine; 4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dihydropyridazin-1-yl)piperidine-1-carboxylic acid tert-butyl ester; CAS 1333222-17-5
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridazin-1(2H)-Yl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, 1H/13C NMR and mass spectrometry for structural confirmation, and residual solvent analysis by GC. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.