Description

(R)-5-Methylchroman-4-Amine Hydrochloride is a high-purity chiral amine derivative, a key building block in advanced pharmaceutical synthesis. Its enantiopure nature is critical for developing active pharmaceutical ingredients (APIs) with specific stereochemical requirements, ensuring efficacy and reducing side effects. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in central nervous system (CNS) and cardiovascular drug discovery.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of enantiomerically pure drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used as a chiral auxiliary or building block in stereoselective chemical reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Preclinical Development: Employed in the production of compounds for pharmacological evaluation, toxicology studies, and formulation development.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying biological pathways and target validation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	(R)-5-Methylchroman-4-Amine Hydrochloride
CAS No.	1330286-45-7
Molecular Formula	C10H14ClNO
Molecular Weight	199.68 g/mol
Synonyms	(R)-5-Methyl-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; (4R)-5-Methyl-3,4-dihydro-2H-chromen-4-amine hydrochloride; (R)-5-Methyl-4-aminochroman hydrochloride; (R)-4-Amino-5-methylchroman hydrochloride; (R)-5-Methyl-2,3-dihydro-1-benzopyran-4-amine hydrochloride; (R)-5-Methyl-4-chromanylamine hydrochloride; (R)-5-Methyl-4-chromanamine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-5-Methylchroman-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.