Description

cis-[2-(4-tert-Butyloxycarbonylamino)Cyclohexyloxy]Tetrahydro-2H-Pyran is a sophisticated Boc-protected amino alcohol derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected amine functionality and a stable tetrahydropyranyl (THP) ether group, enabling precise stereochemical control in multi-step synthetic sequences. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where specific stereochemistry is required for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, including protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Research: Used in constructing chiral scaffolds for novel herbicides, fungicides, and plant growth regulators where stereochemistry impacts efficacy.
• Peptidomimetics & PROTACs: Serves as a versatile linker or core component in the design of peptide mimics and Proteolysis Targeting Chimeras (PROTACs).
• Asymmetric Catalysis Ligand Precursor: Employed in the development of novel chiral ligands and organocatalysts for enantioselective transformations.
• Material Science Monomer: Potential use in synthesizing specialized polymers with tailored properties for advanced material applications.
• Academic & Process Chemistry: A valuable reagent for methodological development and scale-up studies in academic and industrial R&D laboratories.

Basic Information

Product Name	cis-[2-(4-tert-Butyloxycarbonylamino)Cyclohexyloxy]Tetrahydro-2H-Pyran
CAS No.	1322625-95-5
Molecular Formula	C₁₆H₂₉NO₄
Molecular Weight	299.41 g/mol
Synonyms	cis-2-[(4-{[(tert-Butoxy)carbonyl]amino}cyclohexyl)oxy]oxane; cis-2-(4-(Boc-amino)cyclohexyloxy)tetrahydro-2H-pyran; cis-N-Boc-4-(2-Tetrahydropyranyloxy)cyclohexylamine; cis-4-(2-Tetrahydropyranyloxy)cyclohexylamine Boc derivative; cis-Boc-NH-C6H10-O-THP; (1R,2S,4S)- or (1S,2R,4R)-2-(4-((tert-Butoxycarbonyl)amino)cyclohexyloxy)tetrahydro-2H-pyran (stereoisomer); THP ether of cis-4-(Boc-amino)cyclohexanol
EINECS	Contact for details

Quality Control

Our cis-[2-(4-tert-Butyloxycarbonylamino)Cyclohexyloxy]Tetrahydro-2H-Pyran is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure high chemical and isomeric purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP principles where applicable, ensuring reliable consistency and traceability for your research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isomeric Purity (Chiral HPLC)	≥ 99.0% cis-isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.