Description

4-Amino-3-(Boc-Amino)-Tetrahydro-2H-Pyran is a high-purity, protected amino alcohol derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile, stereodefined scaffold for constructing complex molecular architectures, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for API development and scale-up.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Peptidomimetic Chemistry: Used to introduce constrained, heterocyclic amino acid analogs into peptide chains to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Agrochemical Synthesis: Building block for creating novel, biologically active compounds with specific stereochemistry for crop protection.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A requested intermediate for custom synthesis projects requiring Boc-protected, multifunctional pyran scaffolds.

Basic Information

Product Name	4-Amino-3-(Boc-Amino)-Tetrahydro-2H-Pyran
CAS No.	1316831-46-5
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	3-((tert-Butoxycarbonyl)amino)-4-aminotetrahydro-2H-pyran; 4-Amino-3-[(tert-butoxycarbonyl)amino]tetrahydro-2H-pyran; 3-(Boc-amino)-4-amino-tetrahydropyran; Boc-protected 3,4-diaminotetrahydropyran; tert-Butyl (4-amino-3,6-dihydro-2H-pyran-3-yl)carbamate (tautomer); 4-Amino-3-(Boc-amino)tetrahydropyran; 3-N-Boc-4-aminotetrahydro-2H-pyran; 4-Amino-3-(tert-butoxycarbonylamino)tetrahydro-2H-pyran
EINECS	Contact for details

Quality Control

Our 4-Amino-3-(Boc-Amino)-Tetrahydro-2H-Pyran is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.