Description

trans-(4-Amino-Tetrahydro-Pyran-3-Yl)-Carbamic Acid tert-Butyl Ester is a high-purity, protected amino acid derivative featuring a tetrahydro-2H-pyran scaffold. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate for the synthesis of complex, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug discovery programs.
• Peptidomimetic Chemistry: Used to incorporate constrained, heterocyclic amino acid motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Medicinal Chemistry Research: Employed as a versatile scaffold for constructing focused libraries in structure-activity relationship (SAR) studies.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthesis to introduce the trans-4-amino-tetrahydropyran moiety.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials.

Basic Information

Product Name	trans-(4-Amino-Tetrahydro-Pyran-3-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	1316830-74-6
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	tert-Butyl N-[trans-4-aminooxan-3-yl]carbamate; trans-3-((tert-Butoxycarbonyl)amino)-4-aminotetrahydropyran; trans-4-Amino-3-((tert-butoxycarbonyl)amino)tetrahydro-2H-pyran; trans-4-Amino-3-Boc-amino-tetrahydropyran; trans-Boc-4-ATHP; (3R,4S)- and (3S,4R)-4-Amino-3-((tert-butoxycarbonyl)amino)tetrahydro-2H-pyran (racemic mixture); 4-Amino-3-N-Boc-aminotetrahydropyran
EINECS	Contact for details

Quality Control

Our trans-(4-Amino-Tetrahydro-Pyran-3-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic characterization are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.