Description

Racemic-(3Ar,5S,7Ar)-tert-Butyl 5-(Hydroxymethyl)Hexahydropyrano[3,2-B]Pyrrole-1(2H)-Carboxylate is a sophisticated chiral building block featuring a fused hexahydropyrano-pyrrolidine scaffold. This compound is of significant value in medicinal chemistry and pharmaceutical research as a key intermediate for the synthesis of complex bioactive molecules. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and biotechnology sectors for constructing novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scalable synthesis of complex drug molecules.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.
• Asymmetric Synthesis: Utilized in the development of stereoselective synthetic routes due to its defined stereocenters.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	Racemic-(3Ar,5S,7Ar)-tert-Butyl 5-(Hydroxymethyl)Hexahydropyrano[3,2-B]Pyrrole-1(2H)-Carboxylate
CAS No.	1310381-24-8
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	tert-Butyl 5-(hydroxymethyl)hexahydropyrano[3,2-b]pyrrole-1(2H)-carboxylate; (3aR,5S,7aR)-tert-Butyl 5-(hydroxymethyl)hexahydropyrano[3,2-b]pyrrole-1(2H)-carboxylate (enantiomer); 1-Boc-5-(hydroxymethyl)hexahydropyrano[3,2-b]pyrrole; Hexahydropyrano[3,2-b]pyrrole-1(2H)-carboxylic acid, 5-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3aR,5S,7aR)-; BOC-protected hydroxymethyl hexahydropyranopyrrolidine; Fused bicyclic pyrrolidine building block.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results are provided with every shipment. We support development and cGMP-grade requirements, with specifications tailored to your project phase.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	Racemic mixture
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.