Description

Arachidonoyl-1-Thio-Glycerol is a specialized synthetic lipid derivative, a thioester analog of arachidonoyl glycerol, designed for advanced biochemical and pharmacological research. This compound serves as a critical tool for studying endocannabinoid signaling pathways, lipid metabolism, and enzyme-substrate interactions. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for target validation, assay development, and the synthesis of novel bioactive molecules.

Application

• Biochemical Research: A key substrate for investigating the activity and inhibition of enzymes like monoacylglycerol lipase (MAGL) and other serine hydrolases involved in endocannabinoid metabolism.
• Pharmaceutical Development: Used in high-throughput screening (HTS) campaigns to identify and characterize novel therapeutic agents targeting lipid-signaling pathways for pain, inflammation, and neurological disorders.
• Lipidomics & Metabolomics: Serves as a reference standard or an internal standard in mass spectrometry-based analyses to quantify lipid species and study metabolic flux.
• Probe Synthesis: Acts as a versatile chemical building block for the synthesis of activity-based probes (ABPs) and fluorescently tagged lipids for cellular imaging and proteomic studies.
• Cell Signaling Studies: Employed in cell-based assays to modulate endogenous cannabinoid levels and study downstream cellular responses, receptor cross-talk, and signal transduction mechanisms.

Basic Information

Product Name	Arachidonoyl-1-Thio-Glycerol
CAS No.	1309664-54-7
Molecular Formula	C23H36O3S
Molecular Weight	392.60 g/mol
Synonyms	1-Thioarachidonoylglycerol; 1-AG thioester; Arachidonoyl thioglycerol; 1-O-Arachidonoyl-1-thio-sn-glycerol; (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoyl-1-thio-glycerol; MAGL substrate analog; sn-1-Arachidonoyl thioester of glycerol
EINECS	Contact for details

Quality Control

Our Arachidonoyl-1-Thio-Glycerol is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity assessment by HPLC and structural confirmation by NMR and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, ethanol, DMF; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.