Description

3-(2-Imidazo[1,2-B]Pyridazin-3-Ylethynyl)-4-Methyl-Benzoic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic benzoic acid structure. This compound is of significant commercial value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Used in the research and development of potent and selective kinase inhibitors due to its imidazopyridazine core.
• Biochemical Tool Compound: Employed in vitro and in vivo to study enzyme function and validate new therapeutic targets.
• Custom Synthesis Building Block: Provided to contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke molecules.

Basic Information

Product Name	3-(2-Imidazo[1,2-B]Pyridazin-3-Ylethynyl)-4-Methyl-Benzoic Acid
CAS No.	1300690-48-5
Molecular Formula	C₁₇H₁₁N₃O₂
Molecular Weight	289.29 g/mol
Synonyms	4-Methyl-3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]benzoic acid; 3-[(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methylbenzoic acid; Benzoic acid, 4-methyl-3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-; 1300690-48-5; 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid
EINECS	Contact for details

Quality Control

Every batch of 3-(2-Imidazo[1,2-B]Pyridazin-3-Ylethynyl)-4-Methyl-Benzoic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.