Description

(2R,3R,6S)-N,6-Bis(4-Fluorophenyl)Tetrahydro-2-(4-Hydroxyphenyl)-2H-Pyran-3-Carboxamide is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the research and development of novel therapeutic agents, particularly in the fields of oncology and metabolic disease. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring precise molecular building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel small-molecule drug candidates targeting specific biological pathways.
• Protease Inhibitor Research: Potential precursor for the development of enzyme inhibitors due to its complex carboxamide and fluorinated aryl structure.
• Kinase Inhibitor Development: Used in medicinal chemistry programs focused on creating selective kinase modulators for cancer therapy.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study protein function and cellular signaling mechanisms.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Academic & Institutional Research: Used in university and research institute laboratories for exploratory synthetic chemistry and pharmacology studies.

Basic Information

Product Name	(2R,3R,6S)-N,6-Bis(4-Fluorophenyl)Tetrahydro-2-(4-Hydroxyphenyl)-2H-Pyran-3-Carboxamide
CAS No.	1296129-15-1
Molecular Formula	C24H21F2NO3
Molecular Weight	409.43 g/mol
Synonyms	N,6-Bis(4-fluorophenyl)tetrahydro-2-(4-hydroxyphenyl)-2H-pyran-3-carboxamide; (2R,3R,6S)-N,6-Bis(4-fluorophenyl)-2-(4-hydroxyphenyl)tetrahydro-2H-pyran-3-carboxamide; 2H-Pyran-3-carboxamide, N,6-bis(4-fluorophenyl)tetrahydro-2-(4-hydroxyphenyl)-, (2R,3R,6S)-; CAS 1296129-15-1; Fluorophenyl Hydroxyphenyl Pyran Carboxamide; Advanced Fluorinated Pyran Intermediate
EINECS	Contact for details

Quality Control

Our (2R,3R,6S)-N,6-Bis(4-Fluorophenyl)Tetrahydro-2-(4-Hydroxyphenyl)-2H-Pyran-3-Carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high stereochemical and chemical purity suitable for demanding pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R,3R,6S isomer)
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.