Description

4,7-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Difluoro-2,1,3-Benzothiadiazole is a high-purity, advanced organic intermediate featuring two pinacol boronate ester groups on a difluorobenzothiadiazole core. This compound is a critical building block in modern organic synthesis, enabling the construction of complex molecular architectures through efficient cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science sectors for creating novel functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring complex conjugated systems.
• Organic Electronic Materials: Serves as a monomer for constructing donor-acceptor polymers and small molecules used in organic photovoltaics (OPVs), organic light-emitting diodes (OLEDs), and field-effect transistors (OFETs).
• Agrochemical Synthesis: Used to introduce the benzothiadiazole moiety into novel fungicides, herbicides, and plant growth regulators via palladium-catalyzed coupling.
• Ligand and Catalyst Development: Employed in the synthesis of novel bidentate ligands and metal-organic frameworks (MOFs) with tailored electronic properties.
• Fluorescent Dye and Sensor Precursor: Acts as a building block for developing advanced fluorophores and chemosensors due to the electron-deficient benzothiadiazole unit.
• Polymer Chemistry: Enables the synthesis of conjugated polymers with precise structural control for specialty plastics and coatings with specific optical or electronic functions.

Basic Information

Product Name	4,7-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Difluoro-2,1,3-Benzothiadiazole
CAS No.	1295502-63-4
Molecular Formula	C20H28B2F2N2O4S
Molecular Weight	456.14 g/mol
Synonyms	5,6-Difluoro-4,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,1,3-benzothiadiazole; 5,6-Difluoro-4,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[c][1,2,5]thiadiazole; 4,7-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-difluorobenzo[c][1,2,5]thiadiazole; 2,1,3-Benzothiadiazole, 4,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-difluoro-; BT-F2-2Bpin; 5,6-Difluoro-4,7-di(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,1,3-benzothiadiazole
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Quality Control

Our 4,7-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Difluoro-2,1,3-Benzothiadiazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.