Description

Methyl n-{[6-Oxo-3-(4-Phenylpiperazin-1-Yl)Pyridazin-1(6H)-Yl]Acetyl}-L-Leucinate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a sophisticated building block for creating targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new drugs, particularly in areas requiring complex heterocyclic and peptidomimetic structures.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new drug candidates.
• Medicinal Chemistry Research: Used as a building block for constructing complex molecules with potential biological activity, particularly those targeting neurological or metabolic pathways.
• API Synthesis: Integral in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs), especially those containing pyridazine and piperazine motifs.
• Bioconjugation & Probe Development: The leucinate ester and acetyl linker make it suitable for creating labeled compounds or probes for biochemical and pharmacological studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic & Institutional Research: Used in university and institutional labs for fundamental research in organic synthesis and drug discovery.

Basic Information

Product Name	Methyl n-{[6-Oxo-3-(4-Phenylpiperazin-1-Yl)Pyridazin-1(6H)-Yl]Acetyl}-L-Leucinate
CAS No.	1291789-98-4
Molecular Formula	C24H32N6O4
Molecular Weight	468.55 g/mol
Synonyms	Methyl N-[(6-oxo-3-(4-phenylpiperazin-1-yl)pyridazin-1-yl)acetyl]-L-leucinate; L-Leucine, N-[(6-oxo-3-(4-phenyl-1-piperazinyl)-1(6H)-pyridazinyl)acetyl]-, methyl ester; Methyl (2S)-2-[[[3-(4-phenylpiperazin-1-yl)-6-oxo-1H-pyridazin-1-yl]acetyl]amino]-4-methylpentanoate; 1291789-98-4; Methyl L-leucinate derivative with pyridazinone-phenylpiperazine; (S)-Methyl 2-((3-(4-phenylpiperazin-1-yl)-6-oxopyridazin-1(6H)-yl)acetamido)-4-methylpentanoate
EINECS	Contact for details

Quality Control

Our Methyl n-{[6-Oxo-3-(4-Phenylpiperazin-1-Yl)Pyridazin-1(6H)-Yl]Acetyl}-L-Leucinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR, MS) to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment. We support development under ICH guidelines and can supply material suitable for use in cGMP environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under inert atmosphere at lower temperatures (e.g., -20°C) to maximize stability. The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.