Description

[4-(Aminomethyl)Piperidin-1-Yl](Tetrahydro-2H-Pyran-4-Yl)Methanone Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique piperidine-pyran hybrid structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical suppliers engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates targeting neurological disorders.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex active pharmaceutical ingredients, especially those containing piperidine and tetrahydropyran motifs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Preclinical Development: Employed in the scale-up synthesis of compounds for pharmacological and toxicological evaluation.
• Chemical Biology Probes: Can be utilized to develop tool compounds for studying biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and custom manufacturing of specialized fine chemicals.

Basic Information

Product Name	[4-(Aminomethyl)Piperidin-1-Yl](Tetrahydro-2H-Pyran-4-Yl)Methanone Hydrochloride
CAS No.	1286275-68-0
Molecular Formula	C12H22N2O2 • HCl
Molecular Weight	262.78 g/mol (Free base: 226.32 g/mol)
Synonyms	1-[(Tetrahydro-2H-pyran-4-yl)carbonyl]-4-(aminomethyl)piperidine hydrochloride; 4-(Aminomethyl)-1-(oxane-4-carbonyl)piperidine hydrochloride; (4-Piperidinylmethyl)carbamic acid tetrahydro-2H-pyran-4-yl ester hydrochloride (tautomeric form); 4-(Aminomethyl)-N-(tetrahydro-2H-pyran-4-yl)piperidine-1-carboxamide hydrochloride; Tetrahydro-2H-pyran-4-carboxylic acid [4-(aminomethyl)piperidin-1-yl]amide hydrochloride
EINECS	Contact for details

Quality Control

Our [4-(Aminomethyl)Piperidin-1-Yl](Tetrahydro-2H-Pyran-4-Yl)Methanone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.