Description

3-Cyano-n-Piperidin-4-Yl-Benzenesulfonamide Hydrochloride is a high-purity, non-natural amino acid derivative and a key sulfonamide-based building block used in advanced pharmaceutical research and development. This compound is valued for its role as a versatile synthetic intermediate, enabling the creation of novel molecular scaffolds with potential biological activity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery programs, particularly in the synthesis of targeted small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its sulfonamide and piperidine pharmacophores.
• Protease Inhibitor Development: Serves as a core scaffold or precursor in the design of enzyme inhibitors, leveraging the sulfonamide group's binding properties.
• Chemical Biology Probes: Employed in the development of tool compounds for target validation and pathway analysis in biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.
• Academic Research: Used in university and institutional labs for exploratory synthetic chemistry and novel methodology development.

Basic Information

Product Name	3-Cyano-n-Piperidin-4-Yl-Benzenesulfonamide Hydrochloride
CAS No.	1286274-75-6
Molecular Formula	C13H16N4O2S • HCl
Molecular Weight	328.82 g/mol (Free base: 292.36 g/mol)
Synonyms	4-[(3-Cyanophenyl)sulfonyl]piperidine hydrochloride; 3-Cyano-N-(piperidin-4-yl)benzenesulfonamide hydrochloride; Benzenesulfonamide, 3-cyano-N-(4-piperidinyl)-, hydrochloride; 4-(3-Cyanobenzenesulfonamido)piperidine hydrochloride; Piperidine, 4-[[(3-cyanophenyl)sulfonyl]amino]-, hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Cyano-n-Piperidin-4-Yl-Benzenesulfonamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF for moisture content, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.