Description

(1R*,4R*)-N1-(Pyridin-2-Ylmethyl)Cyclohexane-1,4-Diamine Dihydrochloride is a high-purity, stereochemically defined diamine derivative, primarily utilized as a sophisticated chiral building block and ligand in advanced chemical synthesis. Its value lies in its ability to impart specific stereochemistry and functionality in the development of complex molecules, particularly in pharmaceutical research. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise molecular scaffolds for catalysis, medicinal chemistry, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) targets.
• Catalyst Ligand Synthesis: Serves as a precursor for the preparation of chiral ligands used in asymmetric catalysis, enabling the synthesis of enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and the optimization of lead compounds due to its rigid cyclohexane backbone and coordinating nitrogen atoms.
• Agrochemical Synthesis: Used in the development of advanced, stereoselective pesticides and herbicides where specific chirality impacts biological activity.
• Chemical Biology Probes: Functionalized to create molecular probes for studying enzyme mechanisms and biological pathways.
• Complex Molecule Construction: Integral in multi-step synthetic routes for natural products and other complex organic molecules requiring a diamino-cyclohexane motif.

Basic Information

Product Name	(1R*,4R*)-N1-(Pyridin-2-Ylmethyl)Cyclohexane-1,4-Diamine Dihydrochloride
CAS No.	1286274-38-1
Molecular Formula	C₁₃H₂₂N₃·2HCl
Molecular Weight	307.25 g/mol (as dihydrochloride salt)
Synonyms	(1R*,4R*)-N-[(Pyridin-2-yl)methyl]cyclohexane-1,4-diamine dihydrochloride; (1R,4R)-N1-(Pyridin-2-ylmethyl)cyclohexane-1,4-diamine dihydrochloride; (1R,4R)-N-(Pyridin-2-ylmethyl)cyclohexane-1,4-diamine dihydrochloride; trans-N1-(2-Pyridylmethyl)cyclohexane-1,4-diamine dihydrochloride; (1R,4R)-N-(2-Pyridinylmethyl)-1,4-cyclohexanediamine dihydrochloride; Py-2-CH2-NH-trans-1,4-diaminocyclohexane dihydrochloride; A chiral diamine ligand precursor
EINECS	Contact for details

Quality Control

Our production of (1R*,4R*)-N1-(Pyridin-2-Ylmethyl)Cyclohexane-1,4-Diamine Dihydrochloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity suitable for research and development applications. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.