Description

(R)-tert-Butyl 3-(Tetrahydro-2H-Pyran-4-Carbonylamino)Piperidine-1-Carboxylate is a high-purity chiral piperidine derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its value lies in its role as a sophisticated building block for the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology industries, where it is used to construct novel drug candidates targeting central nervous system (CNS) disorders, metabolic diseases, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of active pharmaceutical ingredients (APIs) for clinical development and commercial manufacturing.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop novel therapeutic agents.
• Process Chemistry & Scale-Up: Serves as a defined starting material for the development of robust, scalable synthetic routes under GMP conditions.
• Protease Inhibitor Synthesis: A potential precursor in the synthesis of inhibitors targeting various protease enzymes.
• Ligand & Catalyst Development: Can be utilized to create novel chiral ligands or organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Useful for creating tool compounds to study biological pathways and target validation.

Basic Information

Product Name	(R)-tert-Butyl 3-(Tetrahydro-2H-Pyran-4-Carbonylamino)Piperidine-1-Carboxylate
CAS No.	1286208-68-1
Molecular Formula	C16H28N2O4
Molecular Weight	312.41 g/mol
Synonyms	1-Boc-3-[(tetrahydro-2H-pyran-4-yl)carbonylamino]-(3R)-piperidine; (R)-1-Boc-3-(Tetrahydro-2H-pyran-4-carbonylamino)piperidine; (R)-tert-Butyl 3-((tetrahydro-2H-pyran-4-yl)formamido)piperidine-1-carboxylate; (R)-1-(tert-Butoxycarbonyl)-3-[(tetrahydro-2H-pyran-4-yl)carbonylamino]piperidine; (3R)-1-[(1,1-Dimethylethoxy)carbonyl]-3-[[(tetrahydro-2H-pyran-4-yl)carbonyl]amino]piperidine; (R)-Boc-3-(THP-4-carboxamido)piperidine; (R)-N-Boc-3-amino-4-piperidyl THP-4-carboxamide (protected form).
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-(Tetrahydro-2H-Pyran-4-Carbonylamino)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent moisture uptake. Recommended long-term storage at 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.