Description

3,5-Difluoro-4-[(tetrahydro-2H-pyran-4-yl)methoxy]benzenamine is a high-purity, advanced pharmaceutical intermediate featuring a unique benzenamine core substituted with fluorine and a tetrahydropyranylmethoxy group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and target selectivity. It is primarily needed by R&D scientists and process chemists in the pharmaceutical and biotechnology industries for developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel small-molecule drug candidates.
• API Synthesis: Used in the construction of complex molecules targeting protein kinases and other biological receptors.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Preclinical Development: Employed in the synthesis of compounds for pharmacological profiling and toxicology studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production.
• Chemical Library Synthesis: Used to create diverse compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Item	Details
Product Name	3,5-Difluoro-4-[(tetrahydro-2H-pyran-4-yl)methoxy]benzenamine
CAS No.	1284865-66-2
Molecular Formula	C12H15F2NO2
Molecular Weight	243.25 g/mol
Synonyms	3,5-Difluoro-4-[(tetrahydro-2H-pyran-4-yl)methoxy]aniline; 4-[(Oxan-4-yl)methoxy]-3,5-difluoroaniline; 3,5-Difluoro-4-(tetrahydropyran-4-ylmethoxy)benzenamine; 3,5-Difluoro-4-(tetrahydro-2H-pyran-4-ylmethoxy)aniline; 1284865-66-2; Benzenamine, 3,5-difluoro-4-[(tetrahydro-2H-pyran-4-yl)methoxy]-
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-[(tetrahydro-2H-pyran-4-yl)methoxy]benzenamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.