Description

3,3-Difluoro-4-Piperidinone Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated piperidinone scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules where the introduction of fluorine atoms can dramatically enhance metabolic stability and binding affinity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex heterocyclic targets.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, especially kinase inhibitors and central nervous system (CNS) active compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination on pharmacokinetic properties.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides and pesticides with improved efficacy.
• Chemical Biology Probes: Employed in the creation of labeled compounds and probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Item	Details
Product Name	3,3-Difluoro-4-Piperidinone Hydrochloride
CAS No.	1283720-75-1
Molecular Formula	C5H8F2NO • HCl
Molecular Weight	179.58 g/mol
Synonyms	3,3-Difluoropiperidin-4-one hydrochloride; 4-Piperidinone, 3,3-difluoro-, hydrochloride; 3,3-Difluoro-4-oxopiperidine hydrochloride; 3,3-Difluoropiperidin-4-one HCl; 4-Oxo-3,3-difluoropiperidine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3,3-Difluoro-4-Piperidinone Hydrochloride is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications, which are aligned with ICH guidelines for impurities and stability. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.