Description

(E)-3-(Tetrahydro-2H-Pyran-4-Yl)Acrylic Acid CAS NO 1278963-15-7 is a high-purity, functionalized acrylic acid derivative featuring a tetrahydro-2H-pyran-4-yl substituent. This compound serves as a versatile and valuable pharmaceutical intermediate and organic building block for synthesizing complex molecules. It is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced material sectors who require a reliable source of this specific chiral synthon.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting neurological and metabolic disorders.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging its reactive acrylic acid moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Acts as a functional monomer for introducing tetrahydro-pyran groups into specialty polymers, modifying their physical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP guidelines.

Basic Information

Product Name	(E)-3-(Tetrahydro-2H-Pyran-4-Yl)Acrylic Acid
CAS No.	1278963-15-7
Molecular Formula	C8H12O3
Molecular Weight	156.18 g/mol
Synonyms	(E)-3-(Oxan-4-yl)prop-2-enoic acid; (E)-3-(Tetrahydro-2H-pyran-4-yl)acrylic acid; trans-3-(Tetrahydro-2H-pyran-4-yl)acrylic acid; 3-(Tetrahydro-2H-pyran-4-yl)-2-propenoic acid; (E)-3-(Tetrahydropyran-4-yl)acrylic acid; 4-Pyranacrylic acid, tetrahydro-, (E)-; THP-Acrylic Acid derivative; CAS 1278963-15-7
EINECS	Contact for details

Quality Control

Our (E)-3-(Tetrahydro-2H-Pyran-4-Yl)Acrylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and isomeric integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for each shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. For long-term storage, consider holding under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E/Z ratio)	≥ 98:2 (E:Z)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.