Description

(E/Z)-1-[4-(2-Chloroethoxy)Phenyl]-2-(4-Hydroxyphenyl)-1-Phenyl-1-Butene is a high-purity, non-steroidal selective estrogen receptor modulator (SERM) intermediate of significant commercial importance. Its value lies in its critical role as a key building block in the synthesis of advanced pharmaceutical compounds, particularly those targeting hormone-related conditions. This compound is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of selective estrogen receptor modulators (SERMs) and related therapeutic agents.
• Research & Development: Critical material for medicinal chemistry research, structure-activity relationship (SAR) studies, and the development of new drug candidates targeting estrogen receptors.
• Fine Chemical Synthesis: Used in multi-step organic synthesis for constructing complex molecules with specific stereochemistry and functional groups.
• Biochemical Research: Serves as a tool compound in biochemical assays to study estrogen receptor binding, activation, and modulation.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.
• Academic Research: Utilized in university and institutional labs for advanced studies in organic synthesis and pharmacology.

Basic Information

Product Name	(E/Z)-1-[4-(2-Chloroethoxy)Phenyl]-2-(4-Hydroxyphenyl)-1-Phenyl-1-Butene
CAS No.	1276031-01-6
Molecular Formula	C24H23ClO2
Molecular Weight	378.89 g/mol
Synonyms	1-[4-(2-Chloroethoxy)phenyl]-2-(4-hydroxyphenyl)-1-phenyl-1-butene; (E/Z)-Bazedoxifene Intermediate; Bazedoxifene Related Compound; TSE-424 Intermediate; WAY-140424 Intermediate; 1-Butene, 1-[4-(2-chloroethoxy)phenyl]-2-(4-hydroxyphenyl)-1-phenyl-; SERM Intermediate CL-1
EINECS	Contact for details

Quality Control

Our (E/Z)-1-[4-(2-Chloroethoxy)Phenyl]-2-(4-Hydroxyphenyl)-1-Phenyl-1-Butene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring material for GMP starting material registration and pre-clinical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
E/Z Isomer Ratio	Specified on COA
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.