Description

8-Chloro-7-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine is a high-purity, functionalized benzopyran derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, leveraging its halogenated benzopyran structure.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex target molecules.
• Reference Standard: Used as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	8-Chloro-7-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine
CAS No.	1273666-71-9
Molecular Formula	C9H9ClFNO
Molecular Weight	201.63 g/mol
Synonyms	8-Chloro-7-fluoro-3,4-dihydro-2H-chromen-4-amine; 4-Amino-8-chloro-7-fluoro-3,4-dihydro-2H-1-benzopyran; 8-Chloro-7-fluoro-4-aminochroman; 1273666-71-9; 4-Amino-8-chloro-7-fluorochroman
EINECS	Contact for details

Quality Control

Our 8-Chloro-7-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.