Description

5-Chloro-8-Fluorochroman-4-One is a high-purity fluorinated chromanone derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules with potential biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated structure is leveraged for structure-activity relationship (SAR) studies and lead optimization.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the fluorinated chromanone core can contribute to enhanced efficacy and environmental profile.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, enabling the creation of libraries of compounds for high-throughput screening.
• Material Science Research: Investigated as a monomer or additive for specialty polymers and advanced materials requiring specific optical or electronic properties.
• Academic & Contract Research: Utilized in universities and CROs (Contract Research Organizations) for fundamental studies in heterocyclic chemistry and fluorine chemistry.

Basic Information

Product Name	5-Chloro-8-Fluorochroman-4-One
CAS No.	1273653-86-3
Molecular Formula	C9H6ClFO2
Molecular Weight	200.59 g/mol
Synonyms	5-Chloro-8-fluorochroman-4-one; 8-Fluoro-5-chlorochroman-4-one; 4H-1-Benzopyran-4-one, 5-chloro-8-fluoro-2,3-dihydro-; Chroman-4-one, 5-chloro-8-fluoro-; 5-Chloro-8-fluoro-3,4-dihydro-2H-1-benzopyran-4-one
EINECS	Contact for details

Quality Control

Our 5-Chloro-8-Fluorochroman-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.