Description

2,2,2-Trifluoro-n-Hydroxyethanimidamide is a specialized fluorinated amidine derivative, a high-value building block prized for its unique trifluoromethyl and reactive amidoxime functional groups. This compound matters for its role in introducing the metabolically stable trifluoromethyl group into target molecules, significantly enhancing their lipophilicity and biological activity. It is primarily needed by pharmaceutical and agrochemical R&D chemists for the synthesis of novel active ingredients, as well as by advanced material scientists exploring fluorinated polymers and ligands.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the CF3 group improves compound stability and membrane permeability.
• Ligand & Catalyst Development: Serves as a precursor for nitrogen-containing chelating ligands used in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers, resins, and specialty coatings to impart unique surface properties and chemical resistance.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study protein interactions and metabolic pathways.
• Organic Synthesis Building Block: Facilitates the construction of complex heterocycles, such as fluorinated pyrimidines and triazines, via cyclization reactions.

Basic Information

Product Name	2,2,2-Trifluoro-n-Hydroxyethanimidamide
CAS No.	1272972-31-2
Molecular Formula	C2H3F3N2O
Molecular Weight	128.05 g/mol
Synonyms	2,2,2-Trifluoroacetamidoxime; Trifluoroacetamidoxime; 2,2,2-Trifluoroacetamide oxime; 2,2,2-Trifluoro-N'-hydroxyacetimidamide; α,α,α-Trifluoroacetamidoxime; TFA Amidoxime; 2,2,2-Trifluoroethanimidamide, N-hydroxy-; (Z)-2,2,2-Trifluoro-N'-hydroxyacetimidamide
EINECS	Contact for details

Quality Control

Every batch of 2,2,2-Trifluoro-n-Hydroxyethanimidamide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process development. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and other relevant tests, is supplied with each shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.