Description

(4S)-8-Chloro-7-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, offering precise stereochemical control essential for developing active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring fluorinated and chlorinated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and anti-infective therapies.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex APIs where the (4S) stereochemistry and halogenated benzopyran structure are pharmacologically important.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale manufacturing routes for target molecules.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in regulatory filings.

Basic Information

Product Name	(4S)-8-Chloro-7-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine
CAS No.	1272749-46-8
Molecular Formula	C9H9ClFNO
Molecular Weight	201.63 g/mol
Synonyms	(4S)-8-Chloro-7-fluoro-3,4-dihydro-2H-chromen-4-amine; (4S)-8-Chloro-7-fluoro-3,4-dihydro-2H-1-benzopyran-4-amine; 8-Chloro-7-fluoro-3,4-dihydro-2H-1-benzopyran-4-amine (4S)-; (S)-8-Chloro-7-fluoro-3,4-dihydro-2H-chromen-4-amine; 1272749-46-8; 4-Amino-8-chloro-7-fluoro-3,4-dihydro-2H-1-benzopyran, (4S)-; UNII-9I4J8F5F2I; 9I4J8F5F2I
EINECS	Contact for details

Quality Control

Our (4S)-8-Chloro-7-Fluoro-3,4-Dihydro-2H-1-Benzopyran-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.