Description

6,8-Difluoro-3,4-Dihydro-2H-1-Benzopyran-4-Ol is a high-value fluorinated benzopyran derivative, a key chiral building block in advanced organic synthesis. This compound matters for its role as a sophisticated intermediate in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, where its specific stereochemistry and fluorine substitution pattern are critical. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and synthesis of new drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Research: Serves as a building block for developing novel, high-performance pesticides and herbicides with enhanced activity and selectivity.
• Ligand & Catalyst Development: Used in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Employed in the synthesis of advanced organic electronic materials and fluorinated polymers with unique properties.
• Academic & Contract Research: A valuable compound for methodological studies in organic chemistry, particularly in fluorination and heterocycle formation reactions.
• Fine Chemical Synthesis: Integral for creating complex, high-value flavor, fragrance, and specialty chemical compounds.

Basic Information

Product Name	6,8-Difluoro-3,4-Dihydro-2H-1-Benzopyran-4-Ol
CAS No.	1270583-11-3
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	6,8-Difluorochroman-4-ol; 4-Hydroxy-6,8-difluoro-3,4-dihydro-2H-1-benzopyran; 6,8-Difluoro-3,4-dihydro-2H-chromen-4-ol; 6,8-Difluoro-4-hydroxy-3,4-dihydro-2H-chromene; 6,8-Difluoro-4-hydroxy-2H-chromane; (4R/S)-6,8-Difluorochroman-4-ol (racemic mixture); 1270583-11-3
EINECS	Contact for details

Quality Control

Our 6,8-Difluoro-3,4-Dihydro-2H-1-Benzopyran-4-Ol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profiling, to ensure it meets the exacting standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.