Description

1-[2-Fluoro-3-(Trifluoromethyl)Phenyl]Ethan-1-Amine is a high-value fluorinated aromatic amine building block, distinguished by its unique trifluoromethyl and fluoro substituents which impart significant electronic and steric properties. This compound is critical for medicinal chemistry and advanced materials research, where its structure enables the fine-tuning of bioactivity and material characteristics. It is primarily sought after by pharmaceutical R&D teams and specialty chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in CNS and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, leveraging the fluorine atoms for enhanced metabolic stability and lipophilicity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Functional Material Precursor: Incorporated into polymers and liquid crystals to modify thermal stability, solubility, and electronic properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom chemical synthesis services targeting niche and high-value applications.

Basic Information

Product Name	1-[2-Fluoro-3-(Trifluoromethyl)Phenyl]Ethan-1-Amine
CAS No.	1270581-23-1
Molecular Formula	C9H7F4N
Molecular Weight	205.15 g/mol
Synonyms	1-(2-Fluoro-3-(trifluoromethyl)phenyl)ethanamine; α-Methyl-2-fluoro-3-(trifluoromethyl)benzylamine; 2-Fluoro-α-methyl-3-(trifluoromethyl)benzenemethanamine; 1-(2-Fluoro-3-trifluoromethyl-phenyl)-ethylamine; 2-Fluoro-3-(trifluoromethyl)phenethylamine, α-methyl-; 1270581-23-1; Ethan-1-amine, 1-[2-fluoro-3-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our production of 1-[2-Fluoro-3-(Trifluoromethyl)Phenyl]Ethan-1-Amine adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.