Description

Cbz-3,4-Dimethy-D-Phenylalanine is a protected, non-natural amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a crucial chiral building block for the construction of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including protease inhibitors and bioactive peptide libraries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly protease inhibitors and receptor-targeted peptides.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a dimethyl-substituted phenylalanine residue with defined D-configuration.
• Peptidomimetic Design: Essential for creating conformationally constrained peptide analogs to enhance metabolic stability and binding affinity.
• Chemical Biology Research: Employed in the study of enzyme-substrate interactions and the structure-activity relationships (SAR) of bioactive peptides.
• Custom Synthesis: Serves as a starting material for the custom synthesis of specialized amino acids and complex molecular scaffolds for clients.

Basic Information

Product Name	Cbz-3,4-Dimethy-D-Phenylalanine
CAS No.	1270300-38-3
Molecular Formula	C19H21NO4
Molecular Weight	327.38 g/mol
Synonyms	N-Carbobenzoxy-3,4-dimethyl-D-phenylalanine; Z-3,4-Dimethyl-D-Phe-OH; (R)-2-((((Benzyloxy)carbonyl)amino)-3-(3,4-dimethylphenyl)propanoic acid; Cbz-D-3,4-Dimethyl-Phe-OH; Nα-Cbz-3,4-dimethyl-D-phenylalanine; Benzyl (R)-(1-(3,4-dimethylphenyl)-2-carboxyethyl)carbamate; Benzyloxycarbonyl-3,4-dimethyl-D-phenylalanine
EINECS	Contact for details

Quality Control

Our Cbz-3,4-Dimethy-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.