Description

(R)-5,7-Difluorochroman-4-Ol is a chiral fluorinated chroman derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly in areas requiring enantiomerically pure, fluorinated scaffolds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and metabolic conditions.
• Asymmetric Catalysis Research: Used as a substrate or ligand precursor in the development and testing of new chiral catalysts and synthetic methodologies.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies, leveraging the effects of fluorine substitution and chiral centers on bioactivity and metabolic stability.
• Process Chemistry Development: Serves as a reference standard and starting material for optimizing scalable, enantioselective synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Research: Potential intermediate for developing new chiral, fluorinated active ingredients with enhanced efficacy and environmental profile.

Basic Information

Product Name	(R)-5,7-Difluorochroman-4-Ol
CAS No.	1270294-05-7
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	(4R)-5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-ol; (R)-5,7-Difluoro-4-chromanol; (4R)-5,7-Difluorochroman-4-ol; 5,7-Difluorochroman-4-ol (R-enantiomer); (R)-5,7-Difluoro-3,4-dihydro-2H-chromen-4-ol; (R)-4-Hydroxy-5,7-difluorochromane; (R)-5,7-DFC
EINECS	Contact for details

Quality Control

Our (R)-5,7-Difluorochroman-4-Ol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (assay), enantiomeric excess (ee), and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic; handle and store under inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after opening the primary container.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.