Description

(3-Trifluoromethyl-[1,2,4]Triazolo[4,3-B]Pyridazin-6-Ylsulfanyl)-Acetic Acid is a high-value, heterocyclic building block featuring a trifluoromethyl group and a reactive acetic acid side chain. This compound matters for its role as a critical intermediate in the synthesis of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals, where its unique structure imparts desirable biological and physicochemical properties. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new products with enhanced efficacy and patentability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in therapeutic areas targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Research: Serves as a building block for creating new herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group to improve metabolic stability and bioavailability.
• Chemical Biology Probe Development: Used in medicinal chemistry to create tool compounds for target validation and biochemical pathway studies.
• Material Science Precursor: Potential use in synthesizing specialty polymers or ligands for catalysts, exploiting the triazolopyridazine core.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and scale-up projects.

Basic Information

Product Name	(3-Trifluoromethyl-[1,2,4]Triazolo[4,3-B]Pyridazin-6-Ylsulfanyl)-Acetic Acid
CAS No.	1269535-21-8
Molecular Formula	C9H5F3N4O2S
Molecular Weight	290.22 g/mol
Synonyms	2-[(3-Trifluoromethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)thio]acetic acid; 6-Mercapto-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine-6-ylthioacetic acid; (3-Trifluoromethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-ylthio)acetic acid; 3-Trifluoromethyl-[1,2,4]triazolo[4,3-b]pyridazine-6-thioacetic acid; TFMPTAA; CAS 1269535-21-8
EINECS	Contact for details

Quality Control

Our (3-Trifluoromethyl-[1,2,4]Triazolo[4,3-B]Pyridazin-6-Ylsulfanyl)-Acetic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for full traceability and assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.