Description

3-Hydroxycyclobutanecarboxylic Acid is a versatile chiral building block featuring a strained cyclobutane ring system functionalized with both a carboxylic acid and a hydroxyl group. This unique structural motif makes it a valuable intermediate for the synthesis of complex molecules in pharmaceutical research and fine chemical manufacturing. It is particularly sought after by medicinal chemists and process development scientists for constructing novel scaffolds and exploring structure-activity relationships. The compound is supplied with a CAS Registry Number of 1268521-85-2.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in antiviral, anti-inflammatory, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and plant growth regulators with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Monomer or modifier for producing specialty polymers with tailored thermal and mechanical properties.
• Academic & R&D: Essential reagent for methodological studies in organic chemistry, including ring-opening and functionalization reactions of strained systems.
• Flavor & Fragrance Industry: Intermediate for the synthesis of complex aroma chemicals and natural product analogs.

Basic Information

Product Name	3-Hydroxycyclobutanecarboxylic Acid
CAS No.	1268521-85-2
Molecular Formula	C5H8O3
Molecular Weight	116.12 g/mol
Synonyms	3-Hydroxycyclobutanecarboxylic Acid; (1r,3s)-3-Hydroxycyclobutanecarboxylic Acid; (1s,3r)-3-Hydroxycyclobutanecarboxylic Acid; 3-Hydroxycyclobutane-1-carboxylic Acid; trans-3-Hydroxycyclobutanecarboxylic Acid; cis-3-Hydroxycyclobutanecarboxylic Acid; Cyclobutanecarboxylic acid, 3-hydroxy-; 3-HCBA
EINECS	Contact for details

Quality Control

Our 3-Hydroxycyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support compliance with REACH and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (enantiomer-specific grades available)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.