Description

(R)-7,8-Difluorochroman-4-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its core value lies in its enantiomerically pure structure, which is critical for developing active pharmaceutical ingredients (APIs) with specific stereochemical requirements. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of novel therapeutic agents, particularly in the areas of central nervous system (CNS) and cardiovascular diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those targeting neurological and cardiovascular pathways.
• Asymmetric Synthesis: Used as a building block in the construction of complex, enantiomerically pure molecules for medicinal chemistry research.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Process Chemistry & Scale-up: Employed in route scouting and optimization studies for the efficient, large-scale production of target APIs.
• Academic & Contract Research: Utilized in academic laboratories and CROs (Contract Research Organizations) for exploratory research and custom synthesis projects.

Basic Information

Product Name	(R)-7,8-Difluorochroman-4-Amine Hydrochloride
CAS No.	1266231-84-8
Molecular Formula	C9H10ClF2NO
Molecular Weight	221.63 g/mol
Synonyms	(R)-7,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; (4R)-7,8-Difluoro-3,4-dihydro-2H-chromen-4-amine hydrochloride; (R)-7,8-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine HCl; 7,8-Difluorochroman-4-amine hydrochloride (R-enantiomer); (R)-4-Amino-7,8-difluorochroman hydrochloride; (R)-7,8-Difluorochroman-4-ylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-7,8-Difluorochroman-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.