Description

(R)-7-Fluorochroman-4-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is critical for the research and development of novel therapeutic agents, particularly in the central nervous system (CNS) and cardiovascular fields. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in asymmetric synthesis and process chemistry.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting serotonin and adrenergic receptors.
• Asymmetric Synthesis: Serves as a versatile building block for constructing complex molecules with defined stereochemistry in medicinal chemistry programs.
• Neurological Research: Used in the development of potential therapeutics for neurological disorders, leveraging the fluorochroman scaffold's bioactivity.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale production of candidate drugs.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in regulatory submissions.
• Chemical Biology: Useful as a probe or ligand in studying enzyme-substrate interactions and receptor binding assays.

Basic Information

Product Name	(R)-7-Fluorochroman-4-Amine Hydrochloride
CAS No.	1266230-22-1
Molecular Formula	C10H13ClFNO
Molecular Weight	217.67 g/mol
Synonyms	(R)-7-Fluoro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; (4R)-7-Fluoro-3,4-dihydro-2H-chromen-4-amine hydrochloride; (R)-4-Amino-7-fluorochroman hydrochloride; 7-Fluoro-(4R)-chroman-4-amine HCl; (R)-7-Fluorochroman-4-ylamine hydrochloride; (R)-7-FCA HCl; (R)-7-Fluorochroman-4-amine HCl salt
EINECS	Contact for details

Quality Control

Our (R)-7-Fluorochroman-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.