Description

(R)-5,7-Difluorochroman-4-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its specific stereochemistry and difluorinated chroman core, which are critical for developing active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on novel central nervous system (CNS) agents, cardiovascular drugs, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting serotonin and dopamine receptors.
• Agrochemical Research: Used in the development of new fluorinated pesticides and herbicides, where the fluorine atoms can improve lipophilicity and biological activity.
• Asymmetric Synthesis: Serves as a valuable starting material or resolving agent in catalytic asymmetric reactions due to its defined (R)-configuration.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the commercial-scale production of complex molecules.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical development.

Basic Information

Product Name	(R)-5,7-Difluorochroman-4-Amine Hydrochloride
CAS No.	1266229-95-1
Molecular Formula	C9H10F2NO•HCl
Molecular Weight	221.64 g/mol (free base)
Synonyms	(R)-5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-amine hydrochloride; 4-Amino-5,7-difluorochroman hydrochloride, (4R)-; (4R)-5,7-Difluorochroman-4-amine hydrochloride; (R)-4-Amino-5,7-difluorochroman HCl; 5,7-Difluorochroman-4-amine hydrochloride, (R)-; CAS 1266229-95-1
EINECS	Contact for details

Quality Control

Our (R)-5,7-Difluorochroman-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.