Description

4-(Aminomethyl)Tetrahydro-2H-Pyran-4-Carbonitrile Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique bicyclic structure containing both amine and nitrile functional groups. This compound is of significant commercial value for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of complex drug molecules, particularly those targeting the central nervous system.
• API Development: Serves as a crucial precursor in the research and production of new chemical entities (NCEs) and generic APIs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its versatile chemical reactivity.
• Peptidomimetic Synthesis: The aminomethyl and nitrile groups make it a valuable scaffold for constructing peptide-like compounds with enhanced metabolic stability.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for investigating biological pathways and target validation.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects under cGMP conditions.

Basic Information

Product Name	4-(Aminomethyl)Tetrahydro-2H-Pyran-4-Carbonitrile Hydrochloride
CAS No.	1263374-32-8
Molecular Formula	C8H15ClN2O
Molecular Weight	190.67 g/mol
Synonyms	4-(Aminomethyl)tetrahydro-2H-pyran-4-carbonitrile hydrochloride; 4-(Aminomethyl)tetrahydropyran-4-carbonitrile HCl; 4-Cyano-4-(aminomethyl)tetrahydropyran hydrochloride; THP-Aminomethyl-Carbonitrile HCl; 4-(Aminomethyl)-4-cyanotetrahydropyran hydrochloride; 4-(Aminomethyl)oxane-4-carbonitrile hydrochloride
EINECS	Contact for details

Quality Control

Our production of 4-(Aminomethyl)Tetrahydro-2H-Pyran-4-Carbonitrile HCl adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, and our quality systems support development under current Good Manufacturing Practice (cGMP) guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.