Description

(2R,4Ar,7As)-tert-Butyl 2-(Aminomethyl)Hexahydropyrano[2,3-C]Pyrrole-6(2H)-Carboxylate CAS NO 1263283-92-6 is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined fused bicyclic structure. This compound is of critical importance for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutics. It is primarily sought after by research organizations, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in cutting-edge drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for API manufacturing under GMP conditions.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the generation of novel compound libraries.
• Asymmetric Synthesis: Leveraged for its defined stereochemistry to introduce chirality into target molecules, ensuring high enantiomeric purity in the final API.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial drug substances.
• Protease Inhibitor Development: The fused pyranopyrrolidine core structure suggests potential application in the development of protease or enzyme inhibitors.

Basic Information

Product Name	(2R,4Ar,7As)-tert-Butyl 2-(Aminomethyl)Hexahydropyrano[2,3-C]Pyrrole-6(2H)-Carboxylate
CAS No.	1263283-92-6
Molecular Formula	C14H24N2O3
Molecular Weight	268.35 g/mol
Synonyms	tert-Butyl (2R,4aR,7aS)-2-(aminomethyl)tetrahydro-4H-pyrano[2,3-c]pyrrole-6(2H)-carboxylate; (2R,4aR,7aS)-2-(Aminomethyl)octahydropyrano[2,3-c]pyrrole-6-carboxylic acid tert-butyl ester; 1263283-92-6; BOC-protected aminomethyl pyranopyrrolidine; (2R,4aR,7aS)-N-Boc-2-(aminomethyl)hexahydropyrano[2,3-c]pyrrole
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical development. Every batch is subjected to comprehensive analytical testing, including HPLC for purity and chiral purity, NMR for structural confirmation, and mass spectrometry. We provide full traceability and Certificates of Analysis (COA) detailing all critical quality attributes. Our quality management system supports development under GMP-like conditions for non-clinical and clinical supply, ensuring consistency and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.