Description

(4-Fluorotetrahydro-2H-Pyran-4-Yl)Methanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a fluorinated tetrahydropyran scaffold. This compound is valued for its role in medicinal chemistry, particularly as a key building block for the synthesis of novel bioactive molecules and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies, especially for compounds targeting neurological pathways.
• Protease & Enzyme Inhibitor Development: The fluorinated tetrahydropyran moiety is valuable in creating potent inhibitors for various enzymes.
• Chemical Biology Probes: Serves as a precursor for labeled compounds used in target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of specialized, high-value compounds under cGMP conditions.
• Agrochemical Research: Potential intermediate in the development of new fluorinated agrochemicals with enhanced properties.

Basic Information

Product Name	(4-Fluorotetrahydro-2H-Pyran-4-Yl)Methanamine Hydrochloride
CAS No.	1263180-53-5
Molecular Formula	C6H13ClFNO
Molecular Weight	169.62 g/mol
Synonyms	4-(Aminomethyl)-4-fluorotetrahydropyran hydrochloride; (4-Fluorooxan-4-yl)methanamine hydrochloride; 4-Fluoro-4-(aminomethyl)tetrahydro-2H-pyran hydrochloride; 4-Fluoro-4-(aminomethyl)tetrahydropyran HCl; 4-Fluoro-4-(aminomethyl)oxane hydrochloride; 4-Fluoro-4-(aminomethyl)tetrahydro-2H-pyran monohydrochloride; (4-Fluoro-tetrahydro-pyran-4-yl)-methylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (4-Fluorotetrahydro-2H-Pyran-4-Yl)Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.