Description

(1S,2S)-1,2-Bis(3,5-Bis(Trifluoromethyl)Phenyl)Ethane-1,2-Diamine is a high-value, chiral diamine building block characterized by its electron-deficient aromatic rings. This compound matters for its role as a sophisticated ligand and catalyst precursor in asymmetric synthesis, enabling the creation of complex molecules with high enantiomeric purity. It is primarily needed by R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional polymers.

Application

• Asymmetric Catalysis: Serves as a privileged chiral ligand or precursor for metal complexes (e.g., with Ru, Rh, Pd) in enantioselective hydrogenation, C-C bond formation, and other key transformations.
• Pharmaceutical Intermediates: A critical building block for the synthesis of chiral active pharmaceutical ingredients (APIs), particularly those requiring rigid, fluorinated backbones for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced, enantiomerically pure herbicides, fungicides, and insecticides where specific chirality is essential for biological activity.
• Advanced Material Precursors: Employed in the synthesis of chiral polymers, metal-organic frameworks (MOFs), and specialty resins with unique optical or electronic properties.
• Organocatalysis: Can function as a chiral organocatalyst or as a core structure for derivatization into novel catalyst systems for green chemistry applications.
• Chemical Research & Development: A valuable tool compound in academic and industrial labs for exploring new methodologies in fluorine chemistry and stereoselective synthesis.

Basic Information

Product Name	(1S,2S)-1,2-Bis(3,5-Bis(Trifluoromethyl)Phenyl)Ethane-1,2-Diamine
CAS No.	1262516-72-2
Molecular Formula	C18H12F12N2
Molecular Weight	484.29 g/mol
Synonyms	(1S,2S)-1,2-Bis[3,5-bis(trifluoromethyl)phenyl]ethane-1,2-diamine; (1S,2S)-1,2-Bis(3,5-bis(trifluoromethyl)phenyl)ethylenediamine; (S,S)-1,2-Bis(3,5-bis(trifluoromethyl)phenyl)ethane-1,2-diamine; (S,S)-1,2-Bis[3,5-bis(trifluoromethyl)phenyl]ethylenediamine; (1S,2S)-1,2-Diamino-1,2-bis[3,5-bis(trifluoromethyl)phenyl]ethane; Chiral Trifluoromethylated Diamine Ligand; (S,S)-TFDAD; (S,S)-DiPEN-TF12
EINECS	Contact for details

Quality Control

Our (1S,2S)-1,2-Bis(3,5-Bis(Trifluoromethyl)Phenyl)Ethane-1,2-Diamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity standards for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.