Description

5-Methyl-2-(Trifluoromethoxy)Benzenesulfonamide is a high-value, multi-functional sulfonamide derivative featuring a trifluoromethoxy substituent. This compound serves as a critical advanced pharmaceutical intermediate (API Intermediate) and a versatile building block in modern organic synthesis. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients, where its unique structure imparts desirable physicochemical properties to target molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the biological activity of the sulfonamide and trifluoromethoxy groups.
• Material Science Research: Acts as a monomer or additive in the development of specialty polymers with enhanced chemical resistance or specific surface properties.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a molecular probe.

Basic Information

Product Name	5-Methyl-2-(Trifluoromethoxy)Benzenesulfonamide
CAS No.	1261683-36-6
Molecular Formula	C8H8F3NO3S
Molecular Weight	255.21 g/mol
Synonyms	2-(Trifluoromethoxy)-5-methylbenzenesulfonamide; 5-Methyl-2-(trifluoromethoxy)benzene-1-sulfonamide; 1-Methyl-4-(trifluoromethoxy)benzene-2-sulfonamide; Benzenesulfonamide, 5-methyl-2-(trifluoromethoxy)-; α,α,α-Trifluoro-5-methyl-o-anisolsulfonamide
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-(Trifluoromethoxy)Benzenesulfonamide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) documenting all specifications is provided with every shipment to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.