Description

3-Iodo-5-(Trifluoromethyl)Pyridin-2-Yl Trifluoromethanesulfonate is a high-value, multi-functional chemical building block designed for advanced synthetic chemistry. Its core value lies in its dual functionality, featuring both a reactive iodo substituent and a trifluoromethanesulfonate (triflate) leaving group, which enables efficient cross-coupling and nucleophilic substitution reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to construct complex molecules containing the pharmacologically important trifluoromethylpyridine scaffold.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that benefit from the enhanced metabolic stability and bioavailability imparted by the trifluoromethyl group.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of advanced organic electronic materials, such as OLEDs and conductive polymers.
• Cross-Coupling Reactions: The iodo group is highly reactive in palladium-catalyzed couplings (e.g., Suzuki, Stille, Sonogashira) for carbon-carbon bond formation.
• Nucleophilic Substitution: The triflate group is an excellent leaving group for reactions with various nucleophiles, facilitating the introduction of diverse functional groups.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts used in asymmetric synthesis.

Basic Information

Product Name	3-Iodo-5-(Trifluoromethyl)Pyridin-2-Yl Trifluoromethanesulfonate
CAS No.	1261365-51-8
Molecular Formula	C7H2F6INO3S
Molecular Weight	420.06 g/mol
Synonyms	2-(Trifluoromethanesulfonyloxy)-3-iodo-5-(trifluoromethyl)pyridine; 3-Iodo-5-(trifluoromethyl)pyridin-2-yl triflate; 2-Pyridinol, 3-iodo-5-(trifluoromethyl)-, trifluoromethanesulfonate; 5-(Trifluoromethyl)-3-iodopyridin-2-yl trifluoromethanesulfonate; Trifluoromethanesulfonic acid 3-iodo-5-(trifluoromethyl)-2-pyridinyl ester
EINECS	Contact for details

Quality Control

Our 3-Iodo-5-(Trifluoromethyl)Pyridin-2-Yl Trifluoromethanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥97% (by HPLC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and advanced chemical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.