Description

3-Ethynyltetrahydro-2H-Pyran is a versatile heterocyclic building block featuring both an alkyne and a cyclic ether functional group. This unique bifunctional structure makes it a valuable intermediate for synthesizing complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and anti-viral therapies.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Polymer & Material Science: Employed in the synthesis of functionalized polymers, dendrimers, and specialty materials with tailored properties.
• Cross-Coupling Reactions: The terminal alkyne group is ideal for Sonogashira and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Click Chemistry: An excellent substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to create triazole linkages.

Basic Information

Product Name	3-Ethynyltetrahydro-2H-Pyran
CAS No.	1260667-24-0
Molecular Formula	C7H10O
Molecular Weight	110.15 g/mol
Synonyms	3-Ethynyloxane; 3-Ethynyltetrahydropyran; Tetrahydro-2H-pyran-3-ylethyne; 3-Ethynyltetrahydro-2H-pyran; 3-(Ethynyl)tetrahydro-2H-pyran; 2H-Pyran, 3-ethynyltetrahydro-; 3-Ethynyl-tetrahydro-pyran
EINECS	Contact for details

Quality Control

Our 3-Ethynyltetrahydro-2H-Pyran is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.