Description

Methyl 2-Amino-2-(Tetrahydropyran-4-Yl)Acetate Hydrochloride is a high-purity, non-natural amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a rigid, functionalized tetrahydropyran scaffold essential for constructing complex molecular architectures with precise stereochemistry. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), particularly in areas like protease inhibitors and neurological therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors and enzyme modulators.
• Peptidomimetics Research: Used to incorporate constrained, non-proteinogenic amino acid motifs into peptide analogs to enhance metabolic stability and bioavailability.
• Medicinal Chemistry: Serves as a versatile scaffold for constructing focused libraries in structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce chiral centers.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and protein-protein interactions.
• Agrochemical Synthesis: Potential intermediate for creating advanced, chiral active ingredients with specific biological activity.

Basic Information

Product Name	Methyl 2-Amino-2-(Tetrahydropyran-4-Yl)Acetate Hydrochloride
CAS No.	1260637-54-4
Molecular Formula	C9H18ClNO3
Molecular Weight	223.70 g/mol
Synonyms	Methyl 2-amino-2-(tetrahydro-2H-pyran-4-yl)acetate hydrochloride; 2-Amino-2-(tetrahydropyran-4-yl)acetic acid methyl ester hydrochloride; (R/S)-Methyl 2-amino-2-(tetrahydro-2H-pyran-4-yl)acetate hydrochloride; 4-THP-Gly-OMe·HCl; THP-Glycine methyl ester hydrochloride; Methyl (tetrahydropyran-4-yl)glycinate hydrochloride; 1260637-54-4; Methyl α-amino-tetrahydropyran-4-yl-acetate HCl
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Amino-2-(Tetrahydropyran-4-Yl)Acetate Hydrochloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. All materials are characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.